Ulinastatin injection Exporter

Ulinastatin is a protease inhibitor used for the treatment of severe sepsis and mild to severe acute pancreatitis.

Ulinastatin is an acid-resistant protease inhibitor found in human urine and released from the high-molecular-weight precursor I alpha T1. It inactivates many serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, granulocyte elastase, cathepsin, thrombin, and factors IXa, Xa, XIa, and XlIa. However, although ulinastatin is a protease inhibitor, its activity toward various proteases is relatively weak.

Ulinastatin protein has been found in the brain, liver, kidney, gastrointestinal tract, cartilage, plasma, ovarian follicular fluid, amniotic fluid, and urine. Its mRNA has been detected only in the liver, kidney, heart, lungs, and pancreas. The presence of ulinastatin in certain tissues appears to be due to diffusional uptake and retention through cell surfaces. Ulinastatin also potentiates local anti-proteolytic activity on the extracellular matrix (ECM) during tissue remodeling, possibly through noncovalent binding to TSG-6.

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Accreditations

Benin Beninese Agency for Pharmaceutical Regulation (ABRP)
Burkina Faso National Agency for Pharmaceutical Regulation of Burkina Faso (ANRP)
Burundi The Burundian Regulatory Authority for Medicines for Human Use and Food (ABREMA)
Cameroon Directorate of Pharmacy and Medicines and Laboratories (DPML)
Cape Verde Entidade Reguladora Independente da Saúde (ERIS)
Congo Directorate of Pharmacy and Medicines
Egypt The Egyptian Drug Authority (EDA)
Ghana Ghana Food And Drugs Authority
Ivory Coast DPML (Direction of Pharmacy, Medicine and Laboratories)
Kenya Pharmacy and Poisons Board (PPB)
Malawi Pharmacy and Medicines Regulatory Authority (PMRA)
Mali Department of Pharmacy and Medicines
Mauritania Directorate of pharmacy and laboratories and processed by the National Medicines Commission (C.N.M)
Morocco Morocco Ministry of Health
Namibia Namibia Medicines Regulatory Council (NMRC)
Nigeria Nigeria National Agency for Food and Drug Administration and Control
Senegal Agence sénégalaise de Réglementation pharmaceutique
South Africa SAHPRA
Tanzania Autoridad de Medicamentos y Equipos Médicos – TMDA
Tunisia DPM
Uganda National Drug Authority
Zimbabwe Medicines Control Authority of Zimbabwe – MCAZ