Decitabine

is a chemotherapy drug used for blood cancers like Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML). It’s a hypomethylation agent that works by incorporating into DNA, inhibiting DNA methyltransferase, and causing silenced genes (like tumor suppressors) to reactivate, helping bone marrow produce healthy blood cells. Administered intravenously, common side effects include fever, fatigue, infections, and blood count changes,